Obesity promotes prostate cancer by altering gene regulation

ScienceDaily (Sep. 25, 2012) ? Prostate cancer is one of the most common cancers in men and early treatment is usually very successful. However, like other cancers, obesity increases the risk of aggressive prostate disease. New research, published in BioMed Central's open access journal BMC Medicine, finds that the fat surrounding the prostate of overweight or obese men with prostate cancer provides a favorable environment to promote cancer growth.

Fat is a generally underrated organ. Not only is it an energy store but it secretes a wide range of growth factors, cytokines and hormones, including leptin and adiponectin, and is a major player in the immune system, which protects the body from infection and disease. But too much fat can cause these systems to go haywire and can increase risk of diabetes, cardiovascular disease and cancer.

An international team led by Prof Gema Fr?hbeck and Dr Ricardo Ribeiro analyzed fat, from around the prostate, taken from patients undergoing surgery for prostate disease. Samples were included from men with benign prostatic hyperplasia (BPH), prostate cancer (PC), and from men where their cancer was no longer confined to the prostate. The men were also classified as being either lean (BMI<25) or overweight /obese (BMI>25).

Regardless of type of prostate disease the overweight men had different levels of gene activity in the fat surrounding their prostates compared to the lean men. This included genes which encode proteins involved in immunity and inflammation (such as LEP, which encodes the protein leptin), and cell growth and proliferation (including ANGPT1 which encodes angiopoietin 1), fat metabolism and programmed cell death.

Additionally the activity of more genes was altered between hyperplasia and prostate cancer, and between cancer and non-confined cancer, suggesting a gradual increase in dysregulation during cancer progression.

Prof Fr?hbeck explained, "Both LEP and ANGPT1 encode proteins which are thought to have roles beyond adipose tissue itself, especially because prostate cancer cells have receptors for leptin, and angiopoietin 1. Taken together with the abnormal activity levels of other genes they will ultimately foster fat mass growth, reduce immune surveillance, and promote the formation of new blood vessels, so producing a favorable environment for prostate cancer progression."

Dr Ribeiro continued, "In an increasingly obese population, understanding how fat, especially the fat surrounding the prostate, can influence the growth and severity of prostate cancer may provide an opportunity for implementing personalized lifestyle and therapeutic strategies."

This article is part of the thematic series Metabolism, Diet and Disease from BMC Biology and BMC Medicine.

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The above story is reprinted from materials provided by BioMed Central Limited, via AlphaGalileo.

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Journal Reference:

1. Ricardo Ribeiro, C?tia Monteiro, Victoria Catal?n, Pingzhao Hu, Virg?nia Cunha, Amaia Rodr?guez, Javier G?mez-Ambrosi, Avelino Fraga, Paulo Pr?ncipe, Carlos Lobato, Francisco Lobo, Ant?nio Morais, Vitor Silva, Jos? Sanches-Magalh?es, Jorge Oliveira, Francisco Pina, Carlos Lopes, Rui Medeiros and Gema Fr?hbeck. Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue. BMC Medicine, 2012; (in Press)

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/GR9eUT73B4E/120924202530.htm

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Source: http://my.umbc.edu/events/13732

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Boost Your Social Media Marketing With These Tips | Eric Chua ...

All businesses today need to find some way to address the online audience about their company. SEO, article marketing, and a new method is used to do this today. Social media marketing is among the freshest and popular ways of kickstarting a company. If you would also like to use social media marketing to your advantage, simply continue to read this article to pick up some great tips.

Communicate with your customers directly on social media sites as a person representing the company. The customer needs to feel a connection and that they?re being validated. When customers feel they are having a direct, personal conversation, they instinctively feel more connected with the company.

Your social media pages should have buttons all over. In addition, an RSS feed that provides all your updates is a good thing to have. Ensure that this is clearly visible on your websites, blogs, emails and in your signatures when you comment. From each social network profile, link to your various other profiles to allow customers to find you everywhere.

TIP! You should avoid posting more than three updates a day. Frequent updates throughout the day are not appreciated by potential customers and can hurt their impressions of a company instead of improving them.

Make sure you talk to the people who go to your social media site. A single-sided conversation throughout your page can be the end of your business presence. When people leave comments, they are spending time on you, so be courteous and spend time on them.

Ensure that your post features a headline that grabs attention. First impressions are important, and headlines are the first thing a reader sees. You want to be able to catch their attention and make them interested in reading the rest of your article. So be sure to put some thought into coming up with a good one.

TIP! Use catchy titles on YouTube to attract a following. Titles matter! They should be interesting and attention grabbing to lure users into clicking the play button.

Post links to your company blog on all your social media accounts every time you make a new post. Your social media subscribers will see and follow the links to intriguing and fresh content they can enjoy.

Study the ads on the social media websites and you will find many images that are eye catching and interesting. Using photoshopped images is an effective technique because it gets buyers? attention and makes them more likely to click on your ad. A curious person will be much more likely to visit your business page and make a purchase.

You should always reply to the comments people leave on your posts. Once or twice daily, check your profiles, and respond to these questions and comments as needed. If you wish, you can enable emails for every notification that appears on your page. Keep in mind that your response will be visible to everyone, so avoid making silly gaffes.

TIP! Gain exposure by promoting your business through games on Facebook. Using some of the advanced Facebook techniques, you could manage to create a simple game that draws inspiration from your brand or products.

You need to assess the effectiveness of your social media campaigns by studying the results from each program carefully. It?s critical not to make assumptions, just because your day has gone one way or the other. But it is imperative that you can see trends and anticipate your actions based on them.

Apply relevant hash tags whenever possible to boost the number of individuals who see your Twitter content. Some examples for this would be, #dance for dancing tips or for pet tips use #pets. Your tweets will show up more in search results, which means those who don?t currently follow you will start seeing what you are saying.

It is important to used varied content to entice people to follow the social media marketing campaign that you are promoting. Post informative stories from other sources within your niche, or create your own original content. Running contests, asking interesting questions and displaying intriguing pictures are other ideas for possible posts. Find ways to get your followers engaged and involved. Rather than simply product placement, shoot for product engagement. Make it a goal to identify with your customer?s lifestyle, so that they will identify your product in a like manner, rather than viewing it as yet another thing to spend money on.

TIP! Combine email marketing with social media marketing. Include a Twitter or Facebook buttons at the end of any emails and let customers know that you?ll answer their questions personally on those social networks.

Remember what you, and everyone around you, has completed in the past. Keep these things in your mind so that your campaign can be improved upon, which will lead to greater profits. By doing that, you can keep in mind what will and won?t work when you try again.

It might be difficult to get going, but once you start, momentum will gather, and you?ll be on a roll. Countless firms have benefited from social media, and you can do the same. All it really takes is hard work and some help from those with more

Join me on Facebook:

www.facebook.com/maynaseric

Source: http://www.maynaseric.com/boost-your-social-media-marketing-with-these-tips

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China jails ex-police chief Wang for 15 years in murder scandal

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Sports: 'The NFL Beat': Week Three

An NFL weekend is descending upon us, but first, I would like to congratulate you. Your fantasy team had a big win last week.

Even though you may have lost, you are still a winner for having learned a lesson. The same way that failed athletes and coddled child-stars-gone-bad are. A big winner.





We can turn that around this week though.

We are now officially knee-deep in the muck. Our route through this 16-week mess will be determined by our squads' outputs against the likes of the MegatRON Swansons and the Hutto Breadmen.

Swindlers and thieves lie in our path, as do ill-informed charlatans posing as advisory counsel. If there is a player in your league with a team called "Show Me Your TDs," he will generally be the source of this bad advice, and bad advice for real-life decisions as well.

This is "The NFL Beat" and this is week three.

Lions at Titans

Expect a bounce-back game from Lions QB Matt Stafford, the NFC West defenses he has faced are much stiffer than advertised.

Titans RB Chris Johnson is running the ball like he doesn't care about football after getting paid last year and is completely screwing his fantasy owners. Backup RB Javon Ringer has been cleared to play after battling an infection to start the season, and I would not be surprised to see him start to get a heavier workload if Johnson continues at this pace.

Lions WR Calvin Johnson is still Calvin Johnson and he's going to remind his owners why they drafted him in the first round this weekend.

Sleeper Play: Damian Williams, WR Titans: Nate Washington still seems hurt, and I have noticed Williams becoming more involved in the gameplan regardless. He was the second-most targeted Titan in week two and faces the No. 12 matchup for WRs in the Lions.

49ers at Vikings

Vikings RB Adrian Peterson told reporters that the 49ers hadn't seen a run game like theirs when asked about San Francisco's vaunted run defense, which has only allowed one 100-yard rusher in more than 40 games. Here are my thoughts:

1) Shut up and don't give your opponents chalkboard material like this, especially awesome ones.
2) They have faced better run games like the Vikings'.
3) Peterson has never faced a run defense like San Francisco.

Sleeper Play: I love 49ers WR Michael Crabtree as a flex play this week against the No. 8 WR matchup.

Jaguars at Colts

I like both running games in this matchup, and have Jacksonville RB Maurice Jones-Drew and Indianapolis RB Donald Brown ranked higher than the FantasyPros Expert Consensus.

Colts WR Reggie Wayne has been a true fantasy success story thus far this season for owners who picked him up in the middle rounds, but I would temper expectations slightly this week. His rapport and connection with QB Andrew Luck could eventually prove matchup-proof, but the Jacksonville secondary is not kind to opposing WRs according to my system.

Sleeper Play: Donnie Avery, WR Colts: He may have been dropped in your league by an owner who saw the news that WR Austin Collie will be coming back. Colts OC Bruce Arians says they have a "diamond" in Donnie Avery and he's the next Mike Wallace. Collie is a concussion away from retirement. Arguably, about two past.

Rams at Bears

What a horrible display Bears QB Jay Cutler put on last Thursday

. Many who started him last week won't this week, and I wouldn't advise it either. This is a St. Louis secondary who is notorious for getting in people's heads this season, causing both Titus Young and Josh Morgan to draw penalties out of frustration in consecutive weeks. Is Cutler a guy you want "rattled" playing on your fantasy team? He has some upside, but his downside is among the worst in the league because he gives up on games and teammates while under adversity.

Sleeper Play: Look elsewhere.

Bills at Browns

Browns rookie QB Brandon Weeden showed up to play last week, but if you had him in your fantasy lineup, you're doing this completely wrong. Don't expect that again, and congratulations on winning the powerball mega-millions later this year with your run of good fortune.

C.J. Spiller is certainly the best running back on the Bills roster, and an argument can be made that he looks like the best on any NFL roster right now. I have Spiller pegged for a Top 5 performance this week while I have fellow Bills RB Fred Jackson pegged for a lot less work when he returns from injury.

Sleeper Play: Mohammed Massaqoui, WR Browns: My RosterWatch co-host, the Trashman, loves MoMass this week for some reason, and he's the king of trashy WR speculation.

Bucs at Cowboys

This is a new Bucs team that everyone is expecting to revert to their old selves. I'm not so sure they will under new HC Greg Schiano. While this matchup appears good on paper for Cowboys RB DeMarco Murray, I find the Bucs D-line play in weeks one and two to be worrisome to his owners.

I love the Cowboys WRs and TE Jason Witten this week, but I am tempering my expectations for Bucs WR Vincent Jackson after the beastly week-two performance I predicted, as the Cowboys secondary is much improved.

Sleeper Play: Tampa Bay TE Dallas Clark was in on 75% of offensive plays last week while accumulating five targets. The Cowboys represent the fourth-best matchup for opposing TEs according to my system.

Jets at Dolphins

As predicted, Dolphins RB Reggie Bush was an absolute fantasy monster last week, and I expect that to continue. I will be interested to see how carries will be split moving forward as fellow RB Daniel Thomas returns from whatever injury he is battling this time.

What we do know is that Thomas has looked "OK-to-good" in maybe one game during his career, and that rookie Lamar Miller looks to be the player who is coming on as a future role player and fantasy handcuff to Bush.

Sleeper Play: The Dolphins front seven is improving, and I think that (surprise) the Jets will have a bit of a hard time moving the ball on the ground. I rub my crystal ball and see a deep toss to who I think is Jets rookie WR Stephen Hill that could be a fantasy game-maker. He has been dumped in many leagues after a week-one breakout followed by a week-two stinker.

Chiefs at Saints

Saints QB Drew Brees will do his best "Matt Ryan week one" impersonation in New Orleans' return to the dome, and burn the Chiefs en route to earning top fantasy QB honors for week three.

Owners of Chiefs RBs Jamaal Charles and Peyton Hillis are worried for different reasons coming into this game.

While the matchup is the seventh best for RBs, Charles has admitted soreness in his surgically repaired knee and Hillis has been used inconsistently. Owners of both need to keep them on their rosters and hope that in the worst case, you can count on a 7-to-8-point floor from your flex position.

Sleeper Play: Chiefs WR Jonathan Baldwin has been getting more involved and seems poised to finally do something against the No. 3 matchup for fantasy WRs.

Bengals at Redskins

There are very few QBs you should be starting in front of Redskins rookie Robert Griffin III at this point.

If you drafted RG3 as a backup, congratulations. Now is the time to move either him or the player you drafted as your starter to upgrade at another starting position. He may go bananas this week in a beautiful matchup at home against the Bengals.

Bengals RB Benjarvus Green-Ellis is looking better than I can ever recall in his entire career, and is facing a defense that let sixth-round rookie Daryl Robinson run roughshod on them in Steven Jackson's absence last Sunday. Get the Law Firm into your lineups.

Sleeper Play: WR Leonard Hankerson of the Redskins has shown sparks in the past and burned Rams rookie Janoris Jenkins on a deep bomb last week. Pierre Garcon appears to be out, so I expect the production to continue.

Falcons at Chargers

Two teams that present tough matchups basically across the board according to my system, but you have to think that RB Ryan Mathews may do something to help an anemic Chargers run game in his return from what will be looked back on as his "first" injury of 2012.

Chargers TE Antonio Gates has been a full participant in practice, and is always a must-start when he is healthy and Phillip Rivers is throwing the ball. Backup TE Dante Rosario caught what would have been three Gates TDs last week while Gates sat out. His owners were thrilled. Fantasy football is brutal.

Sleeper Play: Jacquizz Rodgers, RB Falcons: Starting RB Michael Turner looks like what I heard someone say on Twitter this week was "a pug trying to roll uphill." That is about right. If Rodgers is available in your league, I would recommend stashing him on the bench if you don't need him this week.

Eagles at Cardinals

According to my system, the Cardinals are trending toward becoming a defensive juggernaut. Poke fun of the horrible QB play in Arizona all you want. They line up and play some D, and like every other underrated NFC West defense, they play tougher when an East Coast opponent visits. I am downgrading all Eagles players this week.

I honestly don't like one single Arizona player in this game, and owners of Arizona WR Larry Fitzgerald:

Hang in there. I'm saying that the same way I would say it to a friend who was terminally ill. I mean it, but I know there's really not much hope for you to hang on to.

Sleeper Play: Uh, no.

Steelers at Raiders

Raiders RB Darren McFadden has been lackluster to start the 2012 season, and there is one reason: The zone blocking scheme employed by OC Greg Knapp.

Run DMC struggled in the system under former HC Tom Cable, and it wasn't until most-recent-former-HC Hue Jackson designed a "body on a body" scheme that McFadden felt comfortable with that he appeared to be reaching his full potential.

McFadden likes to get sprung at the second level and dash to fantasy glory. He does not like flowing laterally behind the line, analyzing a safety then making a cut-and-go move. It isn't his style and it is worrisome to fantasy owners.

I love Steelers QB Ben Roethlisberger again this week because he seems to be riding one of his confidence streaks, and because the Raiders are just awful. They made Ryan Tannehill look like Tom Brady last week.

Sleeper Play: Raiders RB Mike Goodson: We saw that Goodson can go the distance on just one touch last week, and I can see Oakland trying some different personnel groupings and exotic formations as they will likely be mixing things up after an initial struggle to run the ball.

Texans at Broncos

Broncos QB Peyton Manning clearly does not have the arm he used to when systematically, bi-annually dismantling a much lesser Texans team during his time with division-rival Indianapolis. I don't love Manning this week, but if we learned anything in week two, it's that it is unwise to count the man out, even late in games.

Sleeper Play: Look elsewhere

Patriots at Ravens

The Patriots are facing a little bit of adversity with the loss of TE Aaron Hernandez who slated to be QB Tom Brady's No. 1 option in 2012.

This gives owners of WR Wes Welker a small reprieve from what appeared to be a quick decline into fantasy mediocrity. If you are a Welker owner, hope for a big game or two in Hernandez's absence and ship the guy off to a desert island somewhere.

Sleeper Play: Jacoby Jones, WR Ravens: It pains me to say after seeing all the drops and fantasy letdowns during his time with the Texans, but it appears that Jones has carved out a niche as a specialty deep weapon in a new-look, fast-paced Ravens offense.

Packers at Seahawks

I hate this matchup for the Packers. The Seahawks defense is becoming an elite unit who plays much better at home. All your typical Packers are their usual must-starts (no, that does not include James Jones), but I have downgraded the group in my rankings.

I don't think it will exactly be easy for the Seahawks offense, eithe. The Green Bay pass rush will rattle QB Russell Wilson, and I expect a usual, beastly performance out of Marshawn Lynch.

Sleeper Play: Packers WR Randall Cobb: If Cobb is available in your league, grab him. I like Cobb this week because I think it will be the kind of game where HC Mike McCarthy will have to get creative with his play calling and Cobb represents a versatile chess piece that must be accounted for in many different formations.

[Alex Dunlap (follow on Twitter) is a member of the Pro Football Writers of America, the host of RosterWatch on ESPN Radio, founder of Rosterwatch.com, and NFL Columnist for Bleacher Report.]

Source: http://www.austinchronicle.com/blogs/sports/2012-09-22/the-nfl-beat-week-three/

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Welcome To The Long Tail Of Social Media Marketing: Linqia Exits Stealth Mode With $3.5M Series A From Javelin, Esther Dyson

There have been a lot of social marketing efforts aimed squarely at making content go viral, but equally there seems to be a rising trend, fuelled by big data analytics, of brands (and social media sites themselves) looking at ways of targeting very specific groups of users who are the most likely to respond. Linqia, which has developed a platform to deliver highly targeted "stories" to specific audiences, is among the latter group. The company has just exited stealth mode with a $3.475 million Series A round behind it, led by $2.5 million from Jed Katz of Javelin Venture Partners, along with participation from existing angel investors including Esther Dyson, and a plan to transform how social media marketing is done today.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/9xA6LlTlP-g/

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Centrifugal force = gravity?

Let me be the parrot. It is 100% equivalent to a force, in this case, centrifugal. That is the basis of general relativity.

In relativity, being on a source of gravity(say, the earth) causes your time to be slower than someone orbiting above the earth(ignoring speed). Being in a centrifuge will cause your clock to slow down by the same amount as the gravity it would take to give the same force.

As for the wording "does it create gravity". The answer has been provided by Shaula, and it is no. However, does feeling weight from spin give the same effect as gravity? Yes it does. Again, like Shaula pointed out.

The idea that these two things are 100% equivalent kind of modifies the question a bit. Are they really two separate things? Supposedly not. On a more technical level, gravity is caused by energy, not mass. Mass has energy. But a centrifuge seen spinning has more energy than a stationary one. In that sense, it does create an incredibly tiny amount of additional gravity for people trying to weigh it. However, this is nitty gritty stuff and doesn't directly address the question, which itself becomes unclear.

edit: If this is confusing, ignore it. The wording leaves much to be desired.

Source: http://cosmoquest.org/forum/showthread.php/138294-Centrifugal-force-gravity

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